This article discusses the therapy and syndromes of anus disease due to depression syndrome. Anus disease due to depression syndrome refers to anorectal paresthesia caused by emotional factors. It is essentially a kind of depression syndrome but manifests as anorectal diseases. It shows the common characteristics of depression syndrome in etiology and pathogenesis. The diagnosis should exclude the anorectal organic lesions. Modern therapy of traditional Chinese medicine includes dispersing stagnated liver qi for relieving qi stagnation,nourishing heart for tranquillization,benefiting qi for invigorating spleen,promoting blood circulation for removing phlegm. From the drug property of prescriptions,the majority are the treatments based on relieving depression. Anus disease due to depression syndrome normally presents in anorectal neurosis or functional anorectal pain and mental disorders. Modern medicine has confirmed that the mental factors show a close relationship with anorectal paresthesia.