Objective:To observe the clinical efficacy of Chinese medicine with oral administration (Bushen Antai Recipe) and acupoint application (Yishen Baotai Plaster) in the treatment of early threatened abortion with syndrome of kidney deficiency. Methods86 cases patients of early threatened abortion with syndrome of kidney deficiency were randomly divided into the control group and treatment group, 43 cases in each group. The control group was treated with intramuscular injection of progesterone and acupoint application of Yishen Baotai Plaster, the treatment group was treated with Bushen Antai Recipe based on the treatment for the control group. The two groups were treated for 2 weeks with follow-up for 3 months. The clinical efficacy, short-term pregnancy prognosis and medication safety were observed, and the TCM syndrome score and the levels of serum sex hormone were compared, including progesterone (P), estradiol (E,2,) and human chorionic gonadotropin (HCG).  Results:①The clinical total effective rates were 97.7% in the treatment group and 81.4% in the control group. The clinical efficacy of the treatment group was significantly better than the control group (P,<,0.05). ②After the treatment, there was statistically significant difference on the TCM syndrome score between the two groups, and the score of the treatment group was significantly lower than that of the control group (P,<,0.05). ③After treatment, there were statistically significant differences on the levels of P, E2 and HCG between the two groups, and the levels in the treatment group were significantly higher than those in the control group (P,<,0.05). ④The continued pregnancy rates were 97.7% in the treatment group and 83.7% in the control group,with statistically significant difference,and the continued pregnancy rate of the treatment group was significantly higher than that of the control group (P,<,0.05). ⑤There was no statistically significant difference on the incidence rate of adverse reactions between the two groups (4.7% vs 0%) (P,>,0.05).  Conclusion:Therapy of Chinese medicine with oral administration (Bushen Antai Recipe) and acupoint application (Yishen Baotai Plaster) in the treatment of early threatened abortion with syndrome of kidney deficiency can relieve the clinical symptoms of patients, improve the serum levels of sex hormone and pregnancy prognosis, with good safety.