Objective:To observe the effects of Danzhi Jiangtang Capsule on stromal cell-derived factor-1α(SDF-1α), Cystatin C(CysC)and renal vascular ultrasound in patients with early diabetic nephropathy. Methods90 patients with early diabetic nephropathy were randomly divided into the treatment group and control group, 45 cases in each group. The control group was treated with conventional hypoglycemic and antihypertensive drugs, the treatment group was treated with Danzhi Jiangtang Capsule based on the treatment for the control group,with a course of 3 months. The clinical efficacy was observed. The hemodynamic indexes in renal B-ultrasound and related biochemical indexes including fasting plasma glucose (FPG), postprandial 2 h plasma glucose (2 hPG), glycosylated hemoglobin (HbA1c), urinary microalbumin (mAlb), ratio of urinary albumin and creatinine (ACR) and serum creatinine (Scr) were compared, as well as SDF-1α and CysC.  Results:①Finally 44 cases in the control group and 43 cases in the treatment group completed the trial. ②The clinical total effective rates of the treatment group and control group were 86.0% and 59.1% respectively. The clinical efficacy of the treatment group was significantly better than that of the control group (P,<,0.05). ③After treatment, there were no statistically significant differences on the levels of FPG, 2hPG and HbA1c between the two groups (P,>,0.05). ④After treatment, there were statistically significant differences on the levels of mAlb, ACR and Scr between the two groups, and the levels in the treatment group were significantly lower than those in the control group (P,<,0.01). ⑤After treatment, there were statistically significant differences on the levels of SDF-1α and CysC between the two groups, and the improvement in the treatment group was significantly better than that of the control group (P,<,0.05). ⑥After treatment, there was no statistically significant difference on V,max, between the two groups (P,>,0.05). There was statistically significant difference on RI between the two groups (P,<,0.05).  Conclusion:Danzhi Jiangtang Capsule combined with routine western medicine shows good efficacy in the treatment of early diabetic nephropathy. It can reduce the serum CysC level, regulate the SDF-1α level, resist the inflammatory reaction, improve the renal perfusion and protect the renal function of patients.