Objective:To observe the clinical efficacy of Hezhong Jianpi Decoction in the treatment of gastroesophageal reflux disease(GERD). MethodsBy randomized, double-blind and controlled trial,92 GERD patients were randomly divided into the Chinese medicine group and control group,46 cases in each group. The control group was treated with omeprazole capsule and placebo of Hezhong Jianpi Decoction,and the Chinese medicine group was treated with Hezhong Jianpi Decoction and placebo of omeprazole,with a course of 8 weeks. The clinical efficacy was observed,and the changes on reflux disease questionnaire(RDQ),gastroesophageal reflux disease health-related quality of life(GERD-HRQL),Pittsburgh sleep quality index(PSQI)and hospital anxiety and depression scale(HADS) were compared.  Results:①=1\*GB3Finally 85 cases completed the trial,among 43 cases in the Chinese medicine group and 42 cases in the control group. ②For the comparison of RDQ score between treatment before and after,there was statistically significant difference in both groups(P＜0.01). After treatment,there was statistically significant difference on RDQ score between the two groups(P＜0.05). ③The total effective rates were 88.37% in the Chinese medicine group and 80.95% in the control group. The clinical efficacy of the Chinese medicine group was better than that of the control group(P＜0.05). ④In both groups,there were statistically significant differences on scores of GERD-HRQL,PSQI and HADS between treatment before and after(P＜0.01). After treatment,there were statistically significant differences on scores of GERD-HRQL,PSQI and HADS between the two groups(P＜0.05).  Conclusion:Hezhong Jianpi Decoction can significantly improve the clinical symptoms and mental state of patients with gastroesophageal reflux disease,and enhance the quality of life.