Objective:To discuss Professor Liu Fengbin’s medication rules in the treatment of ulcerative colitis based on traditional Chinese medicine(TCM)inheritance support system. MethodsProfessor Liu Fengbin’s prescriptions for ulcerative colitis were collected,the prescription characteristics and medication rules were analyzed by association rule mining and complex system entropy cluster in TCM inheritance support system.  Results:①This study totally included 169 prescriptions involving 126 drugs with a cumulative frequency of 2 248. ②There were 34 kinds of drugs with frequency of usage more than 20 times. Among,12 drugs that with the highest frequency of usage(medication frequency more than 58 times as high frequency drugs)were Huoxiang(Agastaches Herba),Fuling(Poria),Huanglian(Coptidis Rhizoma),Taizishen(Pseudostellariae Radix),Muxiang(Aucklandiae Radix),Baizhu(Atractylodis Macrocephalae Rhizoma),Gancao(Glycyrrhizae Radix),Baihua Sheshecao(Hedyotis Herba),Huotanmu(Polygonum chinensis),Shanyao(Rhizoma Dioscoreae),Wumeitan(charred Mume Fructus),Qingdai(Naturalis Indigo). ③According to the number of prescriptions,the correlation (degree of association between drugs and drugs) was set as 8 and the penalty (parameters to reduce the interference of negative data information) was 2,then the cluster analysis was performed. 17 couplet medicines that correlation coefficient was more than 0.03 were obtained. ④Based on the complex system entropy clustering,under the constraints of correlation degree as 8 and penalty as 2,14 core combinations that contained 3-4 drugs were evolved. On this basis,by unsupervised entropy hierarchical clustering,seven new prescriptions were further combined and evolved.  Conclusion:12 drugs with high frequency of usage,17 commonly used couplet medicines,14 core drug combinations and 7 new prescriptions are summarized. Professor Liu Fengbin has rich clinical experience in the treatment of ulcerative colitis. The products with effects of invigorating spleen for eliminating dampness and clearing heat and promoting diuresis are often used in the treatment,which aim at the pathogenesis of spleen deficiency as root cause and dampness heat as manifestation. TCM inheritance support system can be used for the study of experience of famous and veteran doctors of TCM.