Objective:To observe the clinical efficacy of modified kinesio taping of integrated Chinese and western medicine in the treatment of knee osteoarthritis. Methods150 patients with knee osteoarthritis were randomly divided into the external treatment group of Chinese medicine(Chinese medicine group),external treatment group of western medicine(western medicine group) and integrated Chinese and western medicine group(integrated group),50 cases in each group. The Chinese medicine group was treated with Huangjing Xinshang Ointment,the western medicine group was treated with kinesio taping,and the integrated group was treated with the modified kinesio taping of integrated Chinese and western medicine,with a course of 14 days. The changes on the active range of motion(AROM)in knee and Western Ontario and McMaster Universities(WOMAC)osteoarthritis indexes were observed and compared.  Results:①For the comparison of treatment before and after,there was statistically significant difference on the flexion angle in the Chinese medicine group(P<0.05),and there were statistically significant differences on the angles of flexion,internal rotation and external rotation angle in the western medicine group and integrated group(P<0.05). After treatment,the improvements on the angles of flexion,internal rotation and external rotation angle in the western medicine group and integrated group were obviously better than those in the Chinese medicine group(P<0.05). While there were no statistically significant differences on the angles of flexion,internal rotation and external rotation angle between the western medicine group and integrated group(P＞0.05). ②For the comparison of treatment before and after,there was statistically significant difference on the score of pain in all groups(P<0.05),and there were statistically significant differences on the scores of stiffness and daily activity difficulty in the western medicine group and integrated group(P<0.05),but there were no statistically significant differences on the scores of stiffness and daily activity difficulty in the Chinese medicine group(P＞0.05). After treatment,the scores of pain and daily activity difficulty in the integrated group were obviously lower than those in the western medicine group and Chinese medicine group(P<0.05),the score of stiffness in the western medicine group and integrated group was obviously lower than that in the Chinese medicine group(P<0.05),and there was no statistically significant difference on the score of stiffness between the western medicine group and integrated group(P＞0.05).  Conclusion:Modified kinesio taping of integrated Chinese and western medicine shows good efficacy in the treatment of knee osteoarthritis,which can obviously improve the active range of motion in knee joint of patients,and relieve the symptoms such as pain,stiffness and so on.