Objective:To observe the clinical efficacy of He’s Sangma Xingbei Decoction combined with western medicine in the treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD). Methods60 AECOPD patients randomly divided into the treatment group and control group,30 cases in each group. The control group was treated with the conventional therapy of western medicine,and the treatment group was treated with He’s Sangma Xingbei Decoction combined with the conventional therapy of western medicine,with a course of 14 days. The clinical efficacy was observed,and the changes on the total score of coughing symptom,level of limulus amebocyte lysate test,pulmonary function indexes and dyspnea grades in modified British Medical Research Council(mMRC)questionnaire were compared.  Results:①The clinical total effective rates were 93.33% in the treatment group and 66.67% in the control group. The clinical efficacy of the treatment group was obviously better than that of the control group(P,<,0.05). ②After treatment,there were statistically significant differences on the total score of coughing symptom and level of FEV,1,(%)between the two groups,and the improvement in the treatment group was obviously better than that in the control group(P,<,0.05). ③In both groups,there was statistically significant difference on the level of limulus amebocyte lysate test between treatment before and after(P,<,0.05). For the D-value of level of limulus amebocyte lysate test between treatment before and after,there was statistically significant difference on the D-value between the two groups,and the D-value of the treatment group was greater than that of the control group(P,<,0.05). ④After treatment,there were statistically significant differences on the mMRC grades between the two groups,and the symptom improvement in the treatment group was obviously better than that in the control group(P,<,0.05).  Conclusion:He’s Sangma Xingbei Decoction combined with western medicine shows good efficacy in the treatment of acute exacerbation of chronic obstructive pulmonary disease,which can obviously improve the symptoms of airflow limitation in patients,effectively inhibit the acute inflammatory response and then help to control the illness as soon as possible.