Objective:To observe the clinical efficacy of Modified Buyang Huanwu Granule in the treatment of refractory nephropathy syndrome(RNS). Methods80 RNS patients were randomly divided into the treatment group and control group, 40 cases in each group. The treatment group was treated with the basic therapy of western medicine and Modified Buyang Huanwu Granule,the control group was treated with the basic therapy of western medicine and placebo,with a course of 6 months. The clinical efficacy and medication safety were observed. The changes on the 24 hours urine protein quantitation,renal function indexes,plasma albumin,blood lipid indexes,coagulation indexes,liver function indexes and Chinese medical syndrome score were compared.  Results:①The clinical total effective rates of the treatment and control group were 87.5% and 77.5% respectively,and the clinical efficacy of the treatment group was obviously better than that of the control group(P＜0.05). ②After treatment,there was statistically significant difference on Chinese medical syndrome score between the two groups,and the score of the treatment group was obviously lower than that of the control group(P＜0.05). ③Compared with treatment before,the level of 24 hours urine protein quantitation at each timepoint during treatment was obviously decreased in both groups,with statistically significant differences(P＜0.05). From the 16th week of treatment,there were statistically significant differences on the level of 24 hours urine protein quantitation at same timepoint between the control group and treatment group(P＜0.05). ④In both groups,there were statistically significant differences on the levels of BUN,Scr,ALB,TG,TC and LDL between treatment before and after(P＜0.05). After treatment,the levels of BUN,Scr,TG,TC and LDL in the treatment group were significantly lower than those in the control group(P＜0.05),and the level of ALB in the treatment group was significantly higher than that in the control group(P＜0.05). After treatment,there were statistically significant differences on the levels of FIB and D-D between the control group and treatment group,and the levels in the treatment group were obviously lower than those in the control group(P＜0.05). ⑤There was statistically significant difference on incidence rate of adverse reactions between the two groups,and the incidence rate of the treatment group was obviously lower than that of the control group(P＜0.05).  Conclusion:Modified Buyang Huanwu Granule in the treatment of refractory nephropathy syndrome can significantly reduce the proteinuria,increase the plasma albumin level,alleviate the disorder of lipid metabolism,improve the blood hypercoagulability and protect the renal function.