Objective:To observe the clinical efficacy of Qiaojiafang Granule on Hashimoto thyroiditis. Methods70 patients were randomly divided into the Qiaojiafang Granule(QJF)group and selenium yeast tablet(SY)group,35 cases in each group. The treatment group was orally treated with Qiaojiafang Granule, and the control group was orally treated with selenium yeast tablet. The treatment course was 12 weeks in both groups. The thyroid function indexes including serum free triiodothyronine (FT,3,),serum free thyroxine(FT,4,) and thyrotropin(TSH),and the levels of thyroid associated antibodies including thyroid peroxidase antibody(TPOAb),thyroglobulin antibody(TGAb)and thyrotropin receptor antibody(TRAb)were observed before and after treatment. And the clinical efficacy was evaluated.  Results:Compared with treatment before,there were no obvious changes on the levels of FT,3,FT,4, and TSH in both groups after treatment(P,>,0.05). Compared with treatment before,the levels of TPOAb and TGAb were obviously decreased in the QJF group after treatment(P,<,0.05),but no obvious change on TRAb level was observed. In the SY group,there were no statistically significant differences on the levels of TPOAb,TGAb and TRAb between treatment before and after(P,>,0.05). After treatment,the levels of TPOAb and TGAb in the QJF group were lower than those in the SY group(P,<,0.05). The clinical efficacy on Chinese medical syndrome of the QJF group was obviously better than that of the SY group(P,<,0.01).  Conclusion:Qiaojiafang Granule can obviously reduce the levels of thyroid associated antibodies in patients with Hashimoto thyroiditis,and its efficacy is better than selenium yeast tablet.