Objective:To observe the clinical efficacy of massage therapy combined with conventional western medicine in the treatment of mild-to-moderate carpal tunnel syndrome. Methods110 patients with carpal tunnel syndrome were randomly divided into the control group and treatment group,55 cases in each group. The control group was treated with conventional and conservative therapy of western medicine,the treatment group was additionally treated with massage based on the treatment for the control group,with a course of one month. The Boston carpal tunnel questionnaire(BCTQ)scores,visual analogue scale(VAS)score and electrophysiological indexes of median nerve that including sensory nerve action potential(SNAP),sensory nerve conduction velocity(SNCV),compound muscle action potential(CMAP)and distal motor latency(DML)were observed and compared.  Results:①During trial,totally 7 cases fell off. Finally 54 cases in the treatment group and 49 cases in the control group completed the trial. ②After treatment,there were statistically significant differences on the BCTQ scores of symptom dimension and functional dimension between the two groups,and the scores of the treatment group were obviously lower than those of the control group(P＜0.05). ③After treatment,there was statistically significant difference on the VAS score between the two groups,and the VAS score of the treatment group was obviously lower than that of the control group(P＜0.05). ④After treatment,the levels of SNAP and SNCV of middle finger-wrist, SNAP and SNCV of thumb-wrist and CMAP of abductor pollicis brevis in the treatment group were obviously increased compared with the control group(P＜0.05),and the DML level in the treatment group was obviously decreased compared with the control group(P＜0.05).  Conclusion:Massage combined with conventional western medicine in the treatment of mild-to-moderate carpal tunnel syndrome can restore the function of hands and wrist,relieve the pain and promote the recovery of local nerve function.