Objective:To observe the clinical efficacy of Compound Wuzi Oral Liquid in the treatment of female urethral syndrome. Methods81 patients with female urethral syndrome were randomly divided into the treatment group(40 cases)and control group(41 cases). The control group was treated with tolterodine tartrate,the treatment group was treated with Compound Wuzi Oral Liquid,with a course of 2 months. The changes on the Chinese medical syndrome scores(including single item score and total score),serum levels of estradiol(E,2,)and follicle stimulating hormone(FSH)were observed.  Results:①Finally 35 cases in the treatment group and 37 cases in the control group completed the trial. ②Compared with treatment before,the symptom scores on frequent urination,urgent urination and dribbling urination of the control group were obviously decreased after treatment(P＜0.05),but there were no statistically significant differences on the other symptom scores(P＞0.05)；while all single item scores of the treatment group were obviously decreased after treatment(P＜0.05). After treatment,the symptom scores on soreness and weakness of waist and knees,spiritlessness and weakness,fear of cold and coldness in limbs in the treatment group were significantly lower than those in the control group(P＜0.05). After treatment,the total score of Chinese medical syndrome in the treatment group was significantly lower than that in the control group(P＜0.05). ③There were no statistically significant differences on the serum levels of E,2, and FSH in the control group between treatment before and after(P＞0.05),while there were statistically significant differences on the serum levels of E,2, and FSH in the treatment group between treatment before and after(P＜0.05). After treatment,there were statistically significant differences on the serum levels of E,2, and FSH between the control group and treatment group(P＜0.05).  Conclusion:Compound Wuzi Oral Liquid can obviously alleviate the clinical symptoms of patients with female urethral syndrome,such as frequent urination and urgent urination,and improve the estrogen levels.