This paper discusses the therapy and syndrome of constipation due to depression syndrome. Although its disease location is at the large intestine, but the constipation is closely related to the disharmony of five zang viscera caused by five minds. The etiology and pathogenesis involve some aspects as follow:There is connection between the liver and intestine, so liver depression may result in qi stagnation in the large intestine. Excessive worry or thinking may influence the spleen and lung, qi accumulation in the spleen and lung may lead to obstruction in the large intestine, while qi deficiency in the spleen and lung could fail to promote the excretion. Overreaction of five minds may transform into fire and consume the body fluid to cause constipation. Over exertion and fatigue impairing the heart and spleen may induce the deficiency of essence and blood, which fail to nourish the large intestine. The six stagnation diseases caused by seven emotions could bring about food retention, phlegm stagnation and blood stasis, and result in obstruction of intestine. The treatment on constipation due to depression syndrome mainly include the therapy of dispersing stagnated liver qi for relieving stagnation, clearing liver-fire, activating qi for eliminating dampness, relieving epigastric distention and removing stagnation, clearing heart fire for tranquillization, invigorating spleen and nourishing blood, dissipating phlegm and resolving stasis. The key lies in regulating qi activities, clearing stagnation and increasing body fluid to promote the excretion. In modern medicine, acute constipation, irritable bowel syndrome with predominant constipation, functional constipation, functional defecation disorders and other chronic constipation induced by mental and psychological factors, as well as somatization disorder, generalized anxiety disorder, depression and other mental disorders which accompanied by constipation, could be roughly within the scope of constipation due to depression syndrome.