Objective:To observe the clinical efficacy of modified Shuanglu Recipe combined with Shenqi Dihuang Decoction in the treatment of IgA nephropathy proteinuria with deficiency of both qi and yin. Methods58 cases of IgA nephropathywith deficiency of both qi and yin were selected. By a randomized,single blind and cross-over study,the patients were randomly divided into the group A and group B,29 cases in each group. The group A was treated with the modified Shuanglu Recipe combined with Shenqi Dihuang Decoction for one course,the discontinue medication was performed for 2 weeks and then the patients were given the Shenqi Dihuang Decoction for one course. The group B was treated with Shenqi Dihuang Decoction for one course,the discontinue medication was performed for 2 weeks and then the patients were given the modified Shuanglu Recipe combined with Shenqi Dihuang Decoction. 8 weeks was taken as one course. The clinical efficacy and medication safety were observed,the changes on Chinese medical syndrome score,related biochemical indexes(24 hours urinary protein quantitation,liver and kidney function and humoral immune indicators)were compared.  Results:①The total effective rates were 61.54% in the treatment group and 38.46% in the control group. There was statistically significant difference on the clinical efficacy between the two groups,and the efficacy of the treatment group was obviously better than that of the control group(P<0.05). ②In both groups,there was statistically significant difference on the Chinese medical syndrome score between treatment before and after(P<0.05). After treatment,there was statistically significant difference on the Chinese medical syndrome score between the two groups,and the score of the treatment group was obviously lower than that of the control group(P<0.05). ③After treatment,there was statistically significant difference on the level of 24 hours urinary protein quantitation between the two groups,the level in the treatment group was obviously lower than that in the control group(P<0.05). There were no statistically significant differences on the levels of serum creatinine(Scr),blood urea nitrogen(BUN),albumin(ALB),alanine aminotransferase(ALT),aspartate aminotransferase(AST)and red blood cells(RBC)between the two groups(P>0.05). ④In both groups,there was statistically significant difference on the level of IgE between treatment before and after(P<0.05),but there were no statistically significant differences on the other indicators between treatment before and after(P>0.05). After treatment,there were no statistically significant differences on the levels of all humoral immune indicators between the two groups(P>0.05).  Conclusion:Modified Shuanglu Recipe combined with Shenqi Dihuang Decoction shows good efficacy in the treatment of IgA nephropathy proteinuria with deficiency of both qi and yin,which can more effectively reduce the proteinuria and protect the renal function of patients.