1. 上海中医药大学附属曙光医院妇科,上海,201203
2. 上海交通大学医学院附属第九人民医院辅助生殖科,上海,200011
扫 描 看 全 文
闫晓彤, 于莎, 艾爱, 等. 齐氏宫腔1方联合宫腔镜治疗宫腔粘连所致胚胎反复移植失败患者的临床观察[J]. 上海中医药杂志, 2017,51(12):58-61.
YAN Xiaotong, YU Sha, AI Ai, et al. Clinical observation on “Qi’s No.1 Recipe for uterine cavity”combined with hysteroscopy in treating patients with embryo recurrent implantation failure caused by intrauterine adhesions[J]. Shanghai Journal of Traditional Chinese Medicine, 2017,51(12):58-61.
闫晓彤, 于莎, 艾爱, 等. 齐氏宫腔1方联合宫腔镜治疗宫腔粘连所致胚胎反复移植失败患者的临床观察[J]. 上海中医药杂志, 2017,51(12):58-61. DOI:
YAN Xiaotong, YU Sha, AI Ai, et al. Clinical observation on “Qi’s No.1 Recipe for uterine cavity”combined with hysteroscopy in treating patients with embryo recurrent implantation failure caused by intrauterine adhesions[J]. Shanghai Journal of Traditional Chinese Medicine, 2017,51(12):58-61. DOI:
目的:观察齐氏宫腔1方联合宫腔镜治疗宫腔粘连所致反复移植失败患者的临床疗效。 方法:将71例宫腔粘连所致胚胎反复移植失败患者(共97个移植周期)随机分为治疗组(35例,47个周期)和对照组(36例,48个周期)。两组均行宫腔镜下宫腔粘连分离术加放环术,治疗组加服齐氏宫腔1方,对照组空白对照,2个月经周期后两组均再次行宫腔镜检查并取环,次月进入移植周期。观察宫腔粘连程度、子宫内膜厚度及临床妊娠结局相关指标的情况。 结果:①组内治疗前后宫腔粘连程度比较,两组差异均有统计学意义(P<0.05);组间治疗后比较,治疗组宫腔粘连改善程度略优于对照组,但两组差异无统计学意义(P>0.05)。②移植日两组子宫内膜厚度比较,差异无统计学意义(P>0.05)。③治疗组、对照组治疗后种植率分别为25.0%、8.0%,两组种植率比较,差异有统计学意义(P<0.05)。治疗组、对照组生化妊娠率分别为42.6%、14.6%,两组生化妊娠率比较,差异有统计学意义(P<0.05)。治疗组、对照组临床妊娠率分别为27.7%、10.4%,两组临床妊娠率比较,差异有统计学意义(P<0.05)。④治疗组、对照组流产率分别为31.6%、44.4%,两组流产率比较,差异无统计学意义(P>0.05)。治疗组、对照组异位妊娠率分别为0.0%、2.1%,两组异位妊娠率差异无统计学意义(P>0.05)。 结论:齐氏宫腔1方联合宫腔镜治疗能够明显提高宫腔粘连所致胚胎反复移植失败患者的种植率及临床妊娠率,其机制可能与改善子宫内膜血供相关。
Objective:To observe the clinical efficacy of“Qi’s No.1 Recipe for uterine cavity”combined with hysteroscopy in the treatment of embryo recurrent implantation failure caused by intrauterine adhesions. Methods71 patients with embryo recurrent implantation failure caused by intrauterine adhesions(total 97 transplant cycles) were randomly divided into the treatment group(35 cases with 47 transplant cycles)and control group(36 cases with 48 transplant cycles). Both groups underwent the hysteroscopic intrauterine adhesions dissection and insertion of intra-uterine device. The treatment group was additionally treated with“Qi’s No.1 Recipe for uterine cavity”,and the control group was taken as the blank control. After 2 menstrual cycles,both groups were performed the hysteroscopy again and the intrauterine device was taken out. The transplant cycle got in the next month.The degree of intrauterine adhesions,endometrial thickness and related indicators of clinical pregnancy outcome were observed. Results:①In both groups,there was statistically significant difference on the degree of intrauterine adhesions between treatment before and after(P<0.05). After treatment,the improvement on intrauterine adhesions in the treatment group was slightly better than that in the control group,but with no statistically significant difference(P>0.05). ②On the day of implantation,there was no statistically significant difference on the endometrial thickness between the two groups(P>0.05). ③After treatment,the implantation rates were 25.0% in the treatment group and 8.0% in the control group,there was statistically significant difference on the implantation rate between the two groups(P<0.05). The biochemical pregnancy rates were 42.6% in the treatment group and 14.6% in the control group,there was statistically significant difference on the biochemical pregnancy rate between the two groups(P<0.05). The clinical pregnancy rates were 27.7% in the treatment group and 10.4% in the control group,there was statistically significant difference on the clinical pregnancy rate between the two groups(P<0.05). ④The abortion rates were 31.6% in the treatment group and 44.4% in the control group,there was no statistically significant difference on the abortion rate between the two groups(P>0.05). The ectopic pregnancy rates were 0.0% in the treatment group and 2.1% in the control group,there was no statistically significant difference on the ectopic pregnancy rate between the two groups(P>0.05). Conclusion:“Qi’s No.1 Recipe for uterine cavity”combined with hysteroscopy can improve the implantation rate and clinical pregnancy rate in patients with embryo recurrent implantation failure caused by intrauterine adhesions. Its mechanism may be associated with the improvement on endometrial blood supply.
宫腔粘连Asherman综合征反复移植失败试管婴儿补肾活血宫腔镜
intrauterine adhesionsAsherman syndromerecurrent implantation failuretest-tube babynourishing kidney and activating bloodhysteroscope
0
浏览量
178
下载量
0
CSCD
11
CNKI被引量
关联资源
相关文章
相关作者
相关机构