Objective:To observe the anti-inflammation and anti-oxidation effects of “Jianpi Bushen Lishi Recipe ” in hyperuricemia nephropathy rats. MethodsThe model of hyperuricemia nephropathy was made by yeast dry powder and adenine in SD rats,and the normal rats were taken as the blank group. After successful modeling,the rats were randomly divided into the model group,Jianpi Bushen Lishi Recipe group and allopurinol group. Each group was treated with the corresponding drugs for 8 weeks. The levels of blood uric acid(BUA),serum creatinine(SCr)and blood urea nitrogen(BUN)were detected. The serum levels of IL-6 and TNF-α were detected by ELISA. The activities of superoxide dismutase (SOD),glutathione peroxidase (GSH-PX) and catalase (CAT) were detected by xanthine oxidase method,DTNB direct coloration and visible spectrophotometry,respectively. The content of malondialdehyde (MDA) was detected by thiobarbituric acid(TBA)method.  Results:There were statistically significant differences on all indicators between the blank group and model group(P<0.05,P<0.01).Compared with the model group,the levels of BUA,SCr,BUN,IL-6 and TNF-α were decreased in the Jianpi Bushen Lishi Recipe group,and the activities of GSH-PX,SOD and CAT were increased and the content of MDA was decreased,with statistically significant differences(P<0.05).Compared with the allopurinol group,the levels of BUA,SCr,BUN,IL-6 and TNF-α were decreased in the Jianpi Bushen Lishi Recipe group,and the activity of GSH-PX was increased and the content of MDA was decreased,with statistically significant differences(P<0.05). There were no statistically significant differences on the activities of SOD and CAT between the allopurinol group and Jianpi Bushen Lishi Recipe(P>0.05).  Conclusion:Jianpi Bushen Lishi Recipe shows good anti-inflammation and anti-oxidation effects,which can positively affect the micro-inflammation and oxidative stress in hyperuricemia nephropathy rats.