Objective:To observe the preventive and therapeutic effects of Zishen Qingqi(ZSQQ)Granule on inflammation in collagen-induced arthritis mice. MethodsDBA/1 mice were randomly divided into the normal group,model group,methotrexate group and ZSQQ groups with low-,middle- and high-dose. Except the normal group,the mice model of collagen-induced arthritis was established in the other groups. From the same day of induction,each group was treated with the corresponding drugs for continuous 3 weeks. The arthritis index was evaluated. The scores on inflammatory mediators and bone destruction in the pathological sections of mouse joint were observed. The serum level of anti-collagen type Ⅱ (CⅡ) specific antibody was detected by ELISA.  Results:Compared with the model group,the arthritis index was effectively decreased in the ZSQQ groups with low-,middle- and high-dose,with statistically significant differences(P<0.05). Compared with the model group,the serum antibody titer of anti- CⅡ was effectively decreased in the ZSQQ group with high-dose,with statistically significant difference(P<0.05). The scores on inflammatory mediators and bone destruction in the ZSQQ groups with low-,middle- and high-dose were all lower than those in the model control group(P<0.05).  Conclusion:Zishen Qingqi Granule Shows the preventive and therapeutic effects in collagen-induced arthritis mice. Its mechanism maybe associated with the decrease in serum level of specific anti-CⅡ antibody in arthritis mice.