Objective:To study the effects of Kangzhi Recipe on regulating glucose and lipid metabolism and improving nonalcoholic steatohepatitis. MethodsSD rats were randomly divided into the normal control group,model group of steatohepatitis,Yishanfu Capsule(polyene phosphatidylcholine capsules)group and Kangzhi Recipe group. Except the normal control group,the other groups were fed with high fat diet and treated with CCl,4, by subcutaneous injection to establish the model. During the modeling,each group was treated with the corresponding drugs by intragastric administration for 8 weeks. The liver function,biochemical indexes,pathological staining of liver tissue and homeostasis model assessment for insulin resistance (HOMA-IR) were routinely detected. The levels of adiponectin (ADP/Acrp3),peroxisome proliferator-activated receptor-α (PPAR-α), tumor necrosis factor-α (TNF-α),fasting insulin (FINS),free fatty acid (FFA) and protein tyrosine kinase (PTK) were detected by ELISA. The expressions of related proteins in insulin signaling pathway were detected by Western blotting.  Results:Compared with the model group of steatohepatitis,the liver function of rats with nonalcoholic steatohepatitis were obviously improved in the Kangzhi Recipe group,and the related pathological characteristics and biochemical indexes were reversed,with statistically significant differences(P,<,0.05,P,<,0.01). And after the treatment of Kangzhi Recipe,the levels of fasting plasma glucose(FPG),FINS and HOMA-IR were decreased(P,<,0.01),the contents of PTK,PPAR-α and ADP were increased(P,<,0.01)and the content of TNF-α was decreased(P,<,0.01),the protein expression of insulin receptor(IR)was increased(P,<,0.01)and the protein expressions of insulin receptor substrate 1(IRS1)and IRS2 were increased(P,<,0.05),the expressions of PI3K and phosphorylated Akt were obviously increased(P,<,0.05)and the expression of phosphorylated p38 was obviously decreased(P,<,0.01). It suggested that the sensitivity of rat hepatocytes to insulin was increased and the insulin signaling transduction was improved.  Conclusion:Kangzhi Recipe can significantly improve nonalcoholic steatohepatitis. Its mechanism may be associated with the regulation on hepatic glucose and lipid metabolism and improvement on insulin signaling pathway.