Objective:To observe the clinical efficacy of acupuncture on Tiantu acupoint(CV22) combined with omeprazole in the treatment of laryngopharyngeal reflux disease. Methods202 patients of laryngopharyngeal reflux disease were randomly divided into the treatment group(102 cases)and control group(100 cases).The control group was orally treated with omeprazole enteric-coated capsule,and the treatment group was treated with acupuncture on Tiantu acupoint based on the treatment for the control group,with a course of 2 months. The clinical efficacy was observed,and the changes on the single item score and total score in reflux symptom index (RSI) scale and reflux finding score (RFS) scale were compared.  Results:①The clinical total effective rates were 78.43% in the treatment group and 63.00% in the control group. The clinical efficacy of the treatment group was significantly better than that of the control group(P<0.05). ②After treatment,there were statistically significant differences on the RSI total score and single item score of persistent throat clearing,cough after meals or lying down,disturbing cough and foreign body sensation in throat between the two groups,and the improvement on the symptoms in the treatment group was obviously better than that in the control group(P<0.05). After treatment,there were statistically significant differences on the RFS total score and single item score of erythema/hyperemia,edema in vocal cords,diffuse laryngeal edema and posterior commissure hyperplasia between the two groups,and the improvement on the signs in the treatment group was obviously better than that in the control group(P<0.05).  Conclusion:Acupuncture on Tiantu acupoint combined with omeprazole by oral administration shows good efficacy in the treatment of laryngopharyngeal reflux disease.