Objective:To study the influence of Jianpi Jiedu Recipe on the expression of vascular endothelial growth factor (VEGF),angiopoietin-2(Ang-2) and basic fibroblast growth factor(bFGF) in Helicobacter pylori(HP)-infected gastric cancer cells,and discuss its possible mechanism. MethodsHuman gastric cancer MKN45 cells were infected by HP standard strain NCTC11637 by co-culture. The cells were divided into the control group,HP infection group,alcohol extract of Jianpi Jiedu Recipe(JPJD)groups with low-,medium- and high-dose(as 0.5 g/L,1.0 g/L and 2.5 g/L respectively).The effects of Jianpi Jiedu Recipe on the expression of VEGF,bFGF and Ang-2 in HP infected MKN45 cells were detected by ELISA. After the inhibition on Wnt/β-catenin activity by the specific inhibitor FH-535 at concentration of 20 μmol/L,the cells were infected by HP once again,and the expression changes of VEGF,bFGF and Ang-2 in MKN45 cells were detected by ELISA. The regulation of Jianpi Jiedu Recipe on the activity of Wnt/β-catenin signaling pathway in HP infected MKN45 cells were determined by Western blotting.  Results:After 12 hours of HP infection,the expression of VEGF,bFGF and Ang-2 in MKN45 cells were obviously up-regulated(P<0.01). The JPJD alcohol extract with low-,medium- and high-dose could all down-regulate the expressions of VEGF,bFGF and Ang-2 in HP infected MKN45 cells,with a certain dose-dependent manner. After the intervention of FH-535,the activity of Wnt/β-catenin was suppressed,the expressions of VEGF,bFGF and Ang-2 were obviously inhibited in HP infected MKN45 cells (P<0.01). After 12 hours of HP infection,the protein expression of β-catenin in cytoplasm and nucleus of MKN45 cells was obviously up-regulated(P<0.01). Jianpi Jiedu Recipe could down-regulate the protein expression of β-catenin in cytoplasm and nucleus,with a certain dose-dependent manner.  Conclusion:Jianpi Jiedu Recipe could down-regulate the expressions of VEGF,bFGF and Ang-2 in HP-infected human gastric cancer cells,and the inhibition on Wnt/β-catenin signaling pathway is one of its mechanisms,which may be its important mechanism in the treatment of gastric cancer.