1. 上海中医药大学附属岳阳中西医结合医院心内科,上海,200437
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周训杰, 姚磊, 符德玉, 等. 活血潜阳祛痰方干预肥胖高血压患者左室重构的临床观察[J]. 上海中医药杂志, 2017,51(9):43-47.
ZHOU Xun-jie, YAO Lei, FU De-yu, et al. Clinical observation of effects of Huoxue Qianyang Qutan Recipe on left ventricular remodeling in obese patients with hypertension[J]. Shanghai Journal of Traditional Chinese Medicine, 2017,51(9):43-47.
周训杰, 姚磊, 符德玉, 等. 活血潜阳祛痰方干预肥胖高血压患者左室重构的临床观察[J]. 上海中医药杂志, 2017,51(9):43-47. DOI:
ZHOU Xun-jie, YAO Lei, FU De-yu, et al. Clinical observation of effects of Huoxue Qianyang Qutan Recipe on left ventricular remodeling in obese patients with hypertension[J]. Shanghai Journal of Traditional Chinese Medicine, 2017,51(9):43-47. DOI:
目的:观察活血潜阳祛痰方治疗肥胖高血压患者的临床疗效及其对左室重构的干预作用。 方法:将90例伴左室重构的肥胖高血压患者随机分为治疗组及对照组,每组45例。对照组维持原西医治疗方案并进行健康宣教,治疗组在对照组治疗措施基础上加用活血潜阳祛痰方。两组疗程均为3个月,观察比较形体学指标、诊室内血压、动态血压、中医证候积分、糖脂代谢指标、心脏结构测定指标的变化情况。 结果:①试验结束时两组完成试验病例共82例,其中治疗组40例、脱落5例,对照组42例、脱落3例,总脱落率约为8.9%。②组间治疗后比较,体质量、腰围及BMI水平差异有统计学意义,治疗组对形体肥胖的改善明显优于对照组(P<0.05)。③组间治疗后比较,诊室内收缩压、舒张压差异有统计学意义,治疗组降压效果明显强于对照组(P<0.05)。④组间治疗后比较,24 h平均收缩压、夜间平均收缩压差异有统计学意义(P<0.05)。⑤组间治疗后比较,中医证候积分差异有统计学意义,治疗组中医证候积分明显低于对照组(P<0.05)。⑥组间治疗后比较,总胆固醇、三酰甘油、低密度脂蛋白、空腹胰岛素、胰岛素抵抗指数水平差异有统计学意义,治疗组明显低于对照组(P<0.05)。⑦组间治疗后比较,室间隔厚度、左心室心肌重量、左心室重量指数水平差异有统计学意义,治疗组较对照组明显下降(P<0.05)。 结论:活血潜阳祛痰方治疗肥胖高血压患者,可明显改善患者肥胖状态及糖脂代谢,可在原有降压方案的基础上进一步改善血压,还可一定程度上改善患者的左室重构。
Objective:To observe the clinical efficacy of Huoxue Qianyang Qutan Recipe in treating obese patients with hypertension and the intervention effects on left ventricular remodeling. Methods90 obese patients with hypertension and left ventricular remodeling were randomly divided into the treatment group and control group,45 cases in each group. The control group was treated with the original therapy of western medicine and health education,and the treatment group was additionally treated with Huoxue Qianyang Qutan Recipe based on the treatment for the control group,with a course of 3 months. The indexes of body shape,blood pressure in consulting room,ambulatory blood pressure,TCM syndrome score,indicators of glucose and lipid metabolism and indexes of cardiac structure were observed and compared. Results:①Until the end of trial,a total of 82 cases completed the whole trial,among 40 cases in the treatment group(5 cases fell off)and 42 cases in the control group(3 cases fell off).The total expulsion rate was 8.9%. ②After treatment,there were statistically significant differences on the levels of body weight,waistline and body mass index(BMI)between the two groups,and the improvement on body obesity in the treatment group was significantly better than that in the control group(P<0.05). ③After treatment,there were statistically significant differences on the systolic and diastolic blood pressure in consulting room between the two groups,and the hypotensive effects of the treatment group were more significant than those of the control group(P<0.05). ④After treatment,there were statistically significant differences on the 24 h mean systolic pressure and night mean systolic pressure between the two groups(P<0.05). ⑤After treatment,there was statistically significant difference on TCM syndrome score between the two groups,and the TCM syndrome score of the treatment group was obviously lower than that of the control group(P<0.05). ⑥After treatment,there were statistically significant differences on the levels of total cholesterol,triacylglycerol,low density lipoprotein,fasting insulin and insulin resistance index between the two groups,and the levels of the treatment group were obviously lower than those of the control group(P<0.05). ⑦After treatment,there were statistically significant differences on the levels of interventricular septal thickness(IVST),left ventricular mass(LVM)and left ventricular mass index(LVMI)between the two groups,and the levels of the treatment group were obviously decreased compared with the control group(P<0.05). Conclusion:Huoxue Qianyang Qutan Recipe can obviously improve the obese condition and glucose and lipid metabolism of obese patients with hypertension,which further improve the blood pressure on the basis of original antihypertensive program and also improve the left ventricular remodeling in a certain extent.
原发性高血压中心性肥胖左室重构糖脂代谢活血潜阳祛痰方
essential hypertensioncentral obesityleft ventricular remodelingglucose and lipid metabolismHuoxue Qianyang Qutan Recipe
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