Objective:To observe the clinical efficacy of Huoxue Zhitong Powder combined with western medicine in the treatment of early diabetic foot. Methods120 patients with early diabetic foot were randomly divided into the treatment group and control group,60 cases in each group. The control group was treated with routine therapy of western medicine,and the treatment group was orally treated with Huoxue Zhitong Powder based on the treatment for the control group,with a course of 20 days. The clinical efficacy was observed,the changes of blood sugar level,ankle-to-brachial ratio index(ABI)and toe-to-brachial ratio index(TBI)in foot,deep and superficial sensation and motor sensory nerve conduction velocity were compared.  Results:①The clinical total effective rate was 80.00% in the treatment group and 55.00% in the control group. The clinical efficacy of the treatment group was significantly better than that of the control group(P<0.05). ②After treatment,there were statistically significant differences on the levels of fasting plasma glucose(FPG)and 2h postprandial glucose(2h PG)between the two groups,and the levels of the treatment group were obviously lower than those of the control group(P<0.05). ③After treatment,there were statistically significant differences on the ABI and TBI between the two groups,the ratio indexes of the treatment group were obviously higher than those of the control group(P<0.05). ④After treatment,there were statistically significant differences on the levels of deep and superficial sensation between the two groups,and the improvement on sensory function in the treatment group was obviously better than that in the control group(P<0.05). ⑤After treatment,there were statistically significant differences on the conduction velocity of common peroneal nerve and median nerve between the two groups,and the conduction velocity in the treatment group were obviously faster than those in the control group(P<0.05).  Conclusion:Huoxue Zhitong Powder combined with western medicine in the treatment of early diabetic foot can obviously alleviate the clinical symptoms of patients,reduce the blood sugar level,improve the deep and superficial sensation and neurological function in foot,and thus effectively control the disease development.