Objective:To evaluate the effects of five kinds extracts of deer antler base on the immunological function in H,22, tumor bearing mice. Methods A total of 90 SPF Kunming mice were randomly divided into the normal control group,model group,positive control group,group of original powder of deer antler base and groups of 5 kinds extracts of deer antler base that treated with acid,base,salt,alcohol and water respectively,10 mice in each group. By the pathological changes of spleen,the percentage of T-lymphocyte subsets CD4,+, and CD8,+, in peripheral blood and spleen and the serum levels of cytokines(IL-6,IL-12)and antibody(IgE,IgG,IgM),the effects of five kinds extracts of deer antler base which extracted by hydrochloric acid,sodium hydroxide,sodium chloride,ethanol and water on the immunological function in tumor bearing mice were evaluated.  Results: Compared with the model group,the 5 kinds extracts of deer antler base could protect the spleen structure of tumor-bearing mice,improve the ratio of CD4,+,/CD8,+, in spleen and peripheral blood(P,<,0.05),and increase the serum levels of IL-6,IL-12 and IgE,IgG,IgM(P,<,0.05).  Conclusion: The alkaline solution extract of deer antler base shows the best effects. Deer antler base may play the antitumor role by improving the humoral and cellular immunity of tumor bearing mice and reversing the inhibition on immunological function caused by tumor.