Through the summary and analysis,this paper reviewed the related mechanism of Qingyi Huaji Recipe. Based on the principle of clearing heat-toxicity and regulating qi-flowing for eliminating dampness,Qingyi Huaji Recipe can stabilize the tumor and prolong the survival time in the treatment of advanced pancreatic cancer. The main mechanism include down-regulating immunosuppressive factors to improve immune suppression,inhibiting tumor associated fibroblasts to improve tumor microenvironment,down-regulating metastasis related gene Ski,decreasing the cell proportion of S phase to inhibit the proliferation of tumor cells,regulating Notch signaling pathway to inhibit protein expression.