Objective:To observe the clinical efficacy of Kuoxin Recipe in the treatment of dilated cardiomyopathy. Methods 88 patients with dilated cardiomyopathy were randomly divided into the treatment group (43cases) and control group (45 cases). Both groups were received the conventional therapy of western medicine,and the treatment group was orally treated with Kuoxin Recipe additionally,with a course of 6 months. The clinical efficacy was observed,the changes of New York Heart Association(NYHA)functional class,related indexes of cardiac ultrasound and serum level of brain natriuretic peptide(BNP)were compared.  Results: ①The clinical total effective rate of the treatment group and control group were 90.70% and 73.33% respectively,the clinical efficacy of the treatment group was significantly better than that of the control group(P<0.05). ②After treatment,the NYHA functional class of the treatment group was significantly better than that of the control group(P<0.05).③After treatment,the levels of cardiac output(CO),cardiac index(CI)and left ventricular ejection fraction(LVEF)in the treatment group were significantly higher than those in the control group(P<0.05),while the levels of left ventricular end diastolic dimension(LVEDd)and BNP were significantly lower than those of the control group(P<0.05).  Conclusion: Kuoxin Recipe can be used in the treatment of dilated cardiomyopathy,which obviously improve the cardiac function,clinical symptoms and life quality of patients.