This paper summarized professor Shi Qi’s experience in treating chronic musculoskeletal diseases with syndrome differentiation of eight principles.Syndrome differentiation of eight principles is an important method to analyze the common characteristics of diseases,which taken as the general principle of various syndrome differentiation methods.In the diagnosis and treatment of chronic musculoskeletal diseases,the holistic view and the theory of perpetual motion should be mastered under the guidance of syndrome differentiation of eight principles,and the therapy ideas of “three insights”(insight into the disease,patient and regularity)should be applied to explore the etiology and achieve the precise syndrome differentiation.As to understanding of the specific disease,it should pay attention to the combination of the targets of lesion,the surroundings of lesion and the overall syndrome characteristics,which would ensure more comprehensive understanding,more precise treatment and more prominent efficacy.The above ideas fully reveal the features and advantages of traditional Chinese medicine.