Chronic musculoskeletal diseases as systemic and local syndromes are mainly caused by natural degeneration of human muscles and bones. Professor Shi Qi has led his team to carry out long-term clinical and basic research on spinal musculoskeletal disease,bone and joint musculoskeletal disease,bone inflammation,bone immune and bone tumor disease. They consider blood stasis due to qi deficiency,essence depletion due to kidney deficiency and bone damage due to marrow depletion as the important pathological basis of musculoskeletal degeneration,and create series technology and programs of prevention and treatment as “harmony therapy”(harmonizing qi and blood,invigorating liver and kidney)and “balance therapy”(regulating muscles and bones,restoring the balance). They establish the translational medicine mode of traditional Chinese medicine in prevention and treatment of chronic musculoskeletal diseases,and form the ideological system of traditional Chinese medicine in prevention and treatment of chronic musculoskeletal diseases.