Objective:To observe the effects of Chuankezhi(CKZ)Injection with continuous airway humidification on mechanical ventilation function of patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD). MethodsEighty AECOPD patients with artificial airway were randomly divided into the treatment group and control group,40 cases in each group. Both groups were treated with conventional therapy (including mechanical ventilation). Meanwhile,the control group was treated with 0.45% normal saline for airway humidification and the treatment group was treated with CKZ for continuous airway humidification by micro pump injection,with a course of 7 days. The clinical efficacy was observed,the changes of respiratory mechanics indexes that included pulmonary static compliance (Cst),pulmonary dynamic compliance (Cdyn),peak airway pressure (PIP),platform pressure (Pplat) and airway resistance (Raw),and the incidence of complications were compared before and after treatment.  Results:①The clinical total effective rate was 95.0% in the treatment group and 82.5% in the control group. The clinical efficacy of the treatment group was better than that of the control group(P<0.05). ②The improvement on all respiratory mechanics indexes in the treatment group was significantly better than that in the control group(P<0.05).③The incidence of complications such as related pneumonia and sputum scab formation in the treatment group was significantly lower than that in the control group(P<0.01).  Conclusion:The treatment with Chuankezhi Injection for continuous airway humidification by micro pump injection can significantly improve the respiratory mechanics in AECOPD patients of mechanical ventilation,reduce the complications and ultimately reduce the time of mechanical ventilation.