Objective:To observe the clinical efficacy of Yan’s Wenyang Huoxue Recipe in the prevention and treatment of restenosis after percutaneous coronary intervention. Methods 60 patients who had received the percutaneous coronary intervention were randomly divided into the treatment group and control group,30 cases in group. The control group was treated with the routine therapy of western medicine, the treatment group was treated with Yan’s Wenyang Huoxue Recipe based on the treatment for the control group,with a course of 3 months. During the follow-up,the cardiovascular events and the restenosis occurrence were observed,the angina-related scores, TCM syndrome scores of blood stasis and chest painful impediment were compared.  Results: ①The incidence rate of restenosis in the treatment group and the control group was 3.33 % and 20.00 %, respectively. The incidence rate of restenosis in the treatment group was significantly lower than that in the control group(P<0.05). ②For the comparison between the two groups after treatment,the differences on the occurrence frequency, duration, pain degree, NTG dosage, grading score of angina and the total score were statistically significant,the improvement on angina symptoms in the treatment group was better than that in the control group(P<0.05). ③For the comparison between the two groups after treatment,the differences on the syndrome scores of chest pain, dark purple tongue with ecchymosis, dark purple lips and gums, sublingual varicose vein and the total score were statistically significant,the improvement on blood stasis syndrome in the treatment group was better than that in the control group(P<0.05). ④For the comparison between the two groups after treatment,the differences on the syndrome scores of oppression in chest,palpitation,fear of cold and cold in limbs,breath shortness and weakness,white complexion and pale lips and the total score were statistically significant,the improvement on syndrome of chest painful impediment was better than that in the control group(P<0.05).  Conclusion: Yan’s Wenyang Huoxue Recipe can be used in the prevention and treatment of restenosis after percutaneous coronary intervention,which significantly decrease the incidence rate of restenosis and improve the clinical symptoms of patients.