Objective:To observe the clinical efficacy of catgut implantation at acupoint in the treatment of insomnia with syndrome of qi and blood deficiency. Methods123 cases of insomnia with syndrome of qi and blood deficiency were randomly divided into the catgut implantation group,acupuncture group and drug group,41 cases in each group. The catgut implantation group was treated with the therapy of catgut implantation at acupoint,the acupuncture group was treated with acupuncture at the same acupoint,the drug group was orally treated with estazolam,with a course of 30 days. The clinical efficacy was observed,and the pittsburgh sleep quality index (PSQI)scores and sleep time were compared.  Results:①Finally 40 cases in the catgut implantation group,39 cases in the acupuncture group and 38 cases in the drug group completed the trial.②At the end of the treatment,the total effective rate of the catgut implantation group,acupuncture group and drug group was 95.00%,87.18% and 65.79% respectively.For the comparison of clinical efficacy between groups,the effect of the catgut implantation group was significantly better than that of the drug group(P<0.05),and equivalent to that of the acupuncture group(P>0.05).When followed-up,the total effective rate of the catgut implantation group,acupuncture group and drug group was 80.00%,61.54% and 39.74% respectively.Compared with the efficacy at the end of treatment,there was a certain degree of recurrence in each group. For the comparison of clinical efficacy between groups,the effect of the catgut implantation group was significantly better than that of the acupuncture group and drug group(P<0.05),but the effect of the acupuncture group was better than that of the drug group(P<0.05).③For the comparison between groups after treatment,the total score of PSQI in the catgut implantation group was equivalent to that of the acupuncture group(P>0.05),and the total score in these two groups was significantly lower than that in the drug group(P<0.05). For the comparison of each sleep-related factor,there were no significant differences between the catgut implantation group and acupuncture group(P>0.05),the scores on sleep quality,fall sleep time, sleep time,sleep efficiency,sleep disorders and daytime function in the catgut implantation group were significantly better than those of the drug group(P<0.05),the scores on sleep quality,fall sleep time,sleep disorders and daytime function in the acupuncture group were significantly better than those of the drug group(P<0.05).④For the comparison of PSQI after treatment and follow-up,the differences on the total score and each sleep-related factor in all groups were statistically significant,which suggested that there was a certain degree of recurrence in each group(P<0.05). For the comparison between groups during follow-up,the total score in the catgut implantation group was significantly lower than that in the acupuncture group and drug group(P<0.05),while the total score in the acupuncture group was equivalent to that of the drug group(P>0.05).For the comparison of each sleep-related factor during follow-up,the scores on sleep quality,fall sleep time,sleep time,sleep efficiency and sleep disorders in the catgut implantation group were still significantly better than those of the drug group(P<0.05),while the scores on sleep quality,sleep time,sleep disorders in the catgut implantation group were significantly better than those of the acupuncture group(P<0.05).⑤For the comparison after treatment and follow-up,the differences on the sleep time in all groups were statistically significant(P<0.05),which suggested that there were recurrence in each group. For the comparison between groups after treatment,the sleep time in the catgut implantation group was significantly longer than that in the acupuncture group and drug group(P<0.05),and the sleep time in the acupuncture group was equivalent to that of the drug group(P>0.05). For the comparison between groups during follow-up,the sleep time in the catgut implantation group was significantly longer than that in the acupuncture group and drug group(P<0.05),and the sleep time in the acupuncture group was significantly longer than that in the drug group(P<0.05).  Conclusion:Catgut implantation at acupoint shows good recent and sustained efficacy in the treatment of insomnia with syndrome of qi and blood deficiency,compared with traditional acupuncture or hypnotic drugs,this therapy is more easily accepted by patients due to the advantages of lower frequency and less time.