This paper mainly discussed the syndromes and treatment of forgetfulness due to depression syndrome. This kind of forgetfulness due to depression syndrome mainly covers depression,anxiety and neurosal hypomnesis in modern medicine,but it dose not generally include the memory loss caused by organic diseases,age-associated memory impairment,cognitive impairment and various dementia. It is mainly caused by emotional factors,the pathogenesis in traditional Chinese medicine include deficiency of heart and spleen,disharmony between heart and kidney,stagnation of liver qi,blood stasis and phlegm turbidity. Also,the clinical features and the medicine treatment in ancient and modern for forgetfulness due to depression syndrome were analyzed.