1. 北京中医药大学2014级硕士研究生班,北京,100029
2. 中国中医科学院广安门医院心内科,北京,100053
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封锐, 胡元会, 褚瑜光, 等. 阴虚阳亢型老年高血压患者动态血压参数特征分析[J]. 上海中医药杂志, 2017,51(1):18-22.
FENG Rui, HU Yuan-hui, CHU Yu-guang, et al. Parametric feature analysis on ambulatory blood pressure in elderly patients with hypertension of yin deficiency and yang excess syndrome[J]. Shanghai Journal of Traditional Chinese Medicine, 2017,51(1):18-22.
封锐, 胡元会, 褚瑜光, 等. 阴虚阳亢型老年高血压患者动态血压参数特征分析[J]. 上海中医药杂志, 2017,51(1):18-22. DOI:
FENG Rui, HU Yuan-hui, CHU Yu-guang, et al. Parametric feature analysis on ambulatory blood pressure in elderly patients with hypertension of yin deficiency and yang excess syndrome[J]. Shanghai Journal of Traditional Chinese Medicine, 2017,51(1):18-22. DOI:
目的:研究阴虚阳亢型老年高血压患者的动态血压参数特征。 方法:选取老年高血压患者114例,其中阴虚阳亢型50例,非阴虚阳亢型64例;对所有患者进行24 h动态血压监测,比较两组患者动态血压参数的差异。 结果:①阴虚阳亢组SBP及脑梗死患病率均高于非阴虚阳亢组(P<0.05),两组血脂、血糖及肝肾功能差异均无统计学意义(P>0.05)。②组间24 h平均收缩压(24 hASBP)、白天平均收缩压(dASBP)、24 h平均脉压(24 hMPP)、白天平均脉压(dMPP)、白天平均动脉压(dMAP)、24 h收缩压变异性(24 hSBPV)、24 h舒张压变异性(24 hDBPV)、白天收缩压变异性(dSBPV)、24 h收缩压负荷(24 hSBPL)、24 h舒张压负荷(24 hDBPL)、白天收缩压负荷(dSBPL)、血压晨峰(MBPP)值比较,阴虚阳亢组大于非阴虚阳亢组(P<0.05)。③组间血压昼夜节律比较,阴虚阳亢组杓型构成比大于非阴虚阳亢组(P<0.05),反杓型构成比小于非阴虚阳亢组(P<0.05)。④Spearman相关性分析结果显示,SBP、合并脑梗死、24 hASBP、dASBP、24 hMPP、dMPP、dMAP、24 hSBPV、24 hDBPV、dSBPV、24 hSBPL、24 hDBPL、dSBPL、MBPP、nSBP下降率,与阴虚阳亢证存在相关性(P<0.05)。⑤二元Logistic回归分析结果显示,dASBP为阴虚阳亢型老年高血压的独立影响因素。 结论:①阴虚阳亢型老年高血压患者动态血压参数变化以收缩压参数升高为主,舒张压参数变化不大,同时伴有血压变异性大、血压负荷增大、晨峰突出及昼夜节律的紊乱。②在所有差异因素中,dASBP与老年高血压患者阴虚阳亢证关系最为密切,或可作为老年高血压阴虚阳亢证的特征性指标;临证应重视阴虚阳亢型患者的动态血压监测,实行辨证论治和个体化治疗,以减少并发症和靶器官损害,提高临床疗效和改善患者的生活质量。
Objective:To study the parametric feature of ambulatory blood pressure in elderly patients with hypertension of yin deficiency and yang excess syndrome. Methods114 cases of elderly patients with hypertension were selected,among 50 cases were of yin deficiency and yang excess syndrome,64 cases were without the syndrome of yin deficiency and yang excess. 24 hours ambulatory blood pressure monitoring was performed in all patients. The differences of ambulatory blood pressure parameters were compared between the two groups. Results:①The systolic blood pressure(SBP)and cerebral infarction rate in the group with syndrome of yin deficiency and yang excess were higher than those in the group without this syndrome(P<0.05). There were no statistically significant differences on the blood lipid,blood glucose and liver and renal function between the two group(P>0.05). ②Comparison between the two group,the values of 24 h average systolic blood pressure (24 hASBP),daytime average systolic blood pressure (dASBP),24 h mean pulse pressure (24 hMPP),daytime mean pulse pressure (dMPP),daytime mean arterial pressure (dMAP),24 h systolic blood pressure variability (24 hSBPV),24 h diastolic blood pressure variability (24 hDBPV),daytime systolic blood pressure variability (dSBPV),24 h systolic blood pressure load(24 hSBPL),24 h diastolic blood pressure load(24 hDBPL),daytime systolic blood pressure load(dSBPL) and morning blood pressure peak (MBPP) in the group with syndrome of yin deficiency and yang excess were higher than those in the group without this syndrome(P<0.05). ③Comparison of circadian rhythm of blood pressure between the two groups,the constituent ratio of dipper in the group with syndrome of yin deficiency and yang excess was higher than that in the group without this syndrome(P<0.05),the constituent ratio of reverse-dipper in the group with syndrome of yin deficiency and yang excess was lower than that in the group without this syndrome(P<0.05). ④Spearman correlation analysis results showed that there were correlation between the existence of yin deficiency and yang excess syndrome and the descend rate of SBP,complicated cerebral infarction,24 hASBP,dASBP,24 hMPP,dMPP,dMAP,24 hSBPV,24 hDBPV,dSBPV,24 hSBPL,24 hDBPL,dSBPL,MBPP,night systolic blood pressure(nSBP)(P<0.05).⑤Binary logistic regression analysis results showed that dASBP was the independent factor for elderly hypertension of yin deficiency and yang excess syndrome. Conclusion:①The parameters changes of ambulatory blood pressure in elderly patients with hypertension of yin deficiency and yang excess syndrome were mainly presented as the increase of systolic blood pressure parameters,and the diastolic blood pressure parameters were not obviously changed,which accompanied by the large blood pressure variability,the increased blood pressure load,the prominent morning peak and the circadian rhythm disorders. ②In all the differential factors,dASBP was most closely related to elderly hypertension of yin deficiency and yang excess syndrome,which may be used as the characteristic index. Clinical application should pay attention to the ambulatory blood pressure monitoring for patients with yin deficiency and yang excess syndrome,and implement the treatment according to syndrome differentiation as well as individualized treatment,so as to reduce the complications and damage of target organs,improve the clinical efficacy and life quality of patients.
高血压老年人阴虚阳亢动态血压
hypertensionelderly peoplesyndrome of yin deficiency and yang excessambulatory blood pressure
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