谷氨酸水解原人参二醇组皂苷制备人参皂苷Rg<sub>3</sub>工艺的优选

夏娟; 张金秋; 阮长春; 李伟; 刘志

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谷氨酸水解原人参二醇组皂苷制备人参皂苷Rg₃工艺的优选

实验研究 | 更新时间：2022-08-31

- 谷氨酸水解原人参二醇组皂苷制备人参皂苷Rg₃工艺的优选
- Process optimization of ginsenoside Rg₃ prepared by hydrolysing protopanaxadiol-type saponins by glutamic acid
- 上海中医药杂志 2017年51卷第1期页码：102-106
- 作者机构：
  
  1. 吉林农业大学农业现代化综合技术研究所,吉林,长春,130118
  2. 吉林农业大学中药材学院,吉林,长春,130118
- 作者简介：
- 基金信息：
  
  国家自然科学基金资助项目(31201331);吉林省高校优秀青年科研人才春苗培育计划资助项目(201448)
- DOI：
  中图分类号：
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夏娟, 张金秋, 阮长春, 等. 谷氨酸水解原人参二醇组皂苷制备人参皂苷Rg₃工艺的优选[J]. 上海中医药杂志, 2017,51(1):102-106.

XIA Juan, ZHANG Jin-qiu, RUAN Chang-chun, et al. Process optimization of ginsenoside Rg₃ prepared by hydrolysing protopanaxadiol-type saponins by glutamic acid[J]. Shanghai Journal of Traditional Chinese Medicine, 2017,51(1):102-106.
夏娟, 张金秋, 阮长春, 等. 谷氨酸水解原人参二醇组皂苷制备人参皂苷Rg₃工艺的优选[J]. 上海中医药杂志, 2017,51(1):102-106. DOI：

XIA Juan, ZHANG Jin-qiu, RUAN Chang-chun, et al. Process optimization of ginsenoside Rg₃ prepared by hydrolysing protopanaxadiol-type saponins by glutamic acid[J]. Shanghai Journal of Traditional Chinese Medicine, 2017,51(1):102-106. DOI：

摘要

目的：研究谷氨酸水解原人参二醇组皂苷制备人参皂苷Rg,3,的最佳工艺。方法：以谷氨酸为催化剂,原人参二醇(PPD)组皂苷为原料,通过单因素考察和正交试验对人参皂苷 Rg,3,的制备工艺进行优化,反应产物用 HPLC 进行定量分析。结果：正交试验优化结果表明,原人参二醇组皂苷(10 g/L)和谷氨酸(10 g/L)于 80 ℃反应 2 h,原人参二醇组皂苷被全部降解,人参皂苷 Rg,3,的转化率可达 65.12%。结论：该法操作简单,成本低,对环境无污染,是一种快速制备20(S)-Rg,3,和20(R)-Rg,3,的可行方法。

Abstract

Objective:To study the optimum process of ginsenoside Rg,3, prepared by hydrolysis protopanaxadiol-type saponins by glutamic acid. MethodsTaken glutamic acid as catalyst and protopanaxadiol(PPD)-type saponins as raw material,the preparation condition of ginsenoside Rg,3, was optimized by single factor investigation and orthogonal test,and the reaction products were quantitatively analyzed by HPLC. Results:The optimization results of orthogonal test showed that all PPD-type saponins were converted when PPD-type saponins (10 g/L) were hydrolyzed by glutamic acid (10 g/L) at 80℃ for 2 h,the conversion rate of ginsenoside Rg,3, was 65.12%. Conclusion:The method is simple in operation,low in cost with no pollution to environment,and is a feasible method for rapid preparation of 20(S)-ginsenoside Rg,3, and 20(R)-ginsenoside Rg,3,.

关键词

人参皂苷Rg3谷氨酸原人参二醇组皂苷酸水解正交试验

Keywords

ginsenoside Rg3glutamic acidprotopanaxadiol-type saponinsacid hydrolysisorthogonal test

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谷氨酸水解原人参二醇组皂苷制备人参皂苷Rg3工艺的优选

Process optimization of ginsenoside Rg3 prepared by hydrolysing protopanaxadiol-type saponins by glutamic acid

DOI：

摘要

Abstract

关键词

Keywords

references

谷氨酸水解原人参二醇组皂苷制备人参皂苷Rg₃工艺的优选

Process optimization of ginsenoside Rg₃ prepared by hydrolysing protopanaxadiol-type saponins by glutamic acid