Objective:To observe the clinical effect of Qingnao Decoction combined with Shuxuetong Injection in the treatment of acute cerebral infarction and its mechanism. Methods60 cases of acute cerebral infarction were randomly divided into the treatment group and control group (30 cases in each group); both groups were received conventional treatment of western medicine, while the control group was treated with Shuxuetong Injection for intravenous infusion, the treatment group was treated orally with Qingnao Decoction based on the treatment for the control group, with a course of 14 days. The changes of National Institutes of Health Stroke Scale (NIHSS) and Barthel Index (BI) in both groups were observed before and after treatment,and the changes of hyperhomocysteinemi(HCY) and D-dimer were detected.  Results:①After treatment, the NIHSS score in both groups were significantly decreased compared with treatment before (P<0.01),and the score of the treatment group was lower than that of the control group (P<0.05);②After the treatment, the BI in both groups were significantly increased compared with treatment before (P<0.01),and the index of the treatment group was higher than that of the control group (P<0.05);③After treatment,the serum contents of HCY and D-dimer in both groups were decreased compared with treatment before(P<0.05,P<0.01),and the contents of the treatment group were lower than those of the control group (P<0.05).  Conclusion:Qingnao Decoction combined with Shuxuetong Injection shows good effects in the treatment of acute cerebral infarction, its mechanism may be related to reducing the serum contents of HCY and D-dimer.