Objective:To observe the clinical efficacy of Zhenjing Xiehuo Granule on mild-to-moderate anxiety with internal disturbance of phlegm-heat. Methods100 cases of mild-to-moderate anxiety with internal disturbance of phlegm-heat were randomly divided into the treatment group and control group,50 cases in each group. The treatment group was given Zhenjing Xiehuo Granule, and the control group was treated with the placebo granule,with a course of 2 months. The Hamilton anxiety(HAMA)scale,self-rating anxiety scale (SAS) score,Pittsburgh sleep quality index (PSQI) score,TCM syndrome score and medication safety were observed.  Results:①93 patients completed the trials in the end,among which 48 in the treatment group and 45 in the control group,7 cases fell off. ②Comparison between the two groups after treatment, there were statistically significant differences on the HAMA and SAS scores,and the scores of the treatment group were decreased more significantly than those of the control group (P<0.05). ③Comparison between the treatment before and after within group,there were statistically significant differences on the PSQI scores in both groups,and the scores were both significantly decreased in the two groups(P<0.05). Comparison of the difference before and after treatment,there were statistically significant differences on the PSQI scores between the two group,and the scores of the treatment group were decreased more significantly than those of the control group (P<0.05). ④Comparison between the treatment before and after within group,there were statistically significant differences on the TCM syndrome scores in both groups,and the scores were both significantly decreased in the two groups(P<0.05). Comparison of the difference before and after treatment,there were statistically significant differences on the TCM syndrome scores between the two group,and the scores of the treatment group were decreased more significantly than those of the control group (P<0.05). ⑤ There was no statistically significant difference on the incidence rate of side effects between the two groups (P>0.05).  Conclusion: Zhenjing Xiehuo Granule shows good efficacy on mild-to-moderate anxiety with internal disturbance of phlegm-heat,which can effectively reduce the anxiety degree of patients and improve the sleep quality.