Objective:To observe the clinical efficacy of Qiangji Tongluo Granules in the treatment of ankylosing spondylitis with syndrome of kidney deficiency and phlegm stasis. Methods 60 patients of ankylosing spondylitis with syndrome of kidney deficiency and phlegm stasis were randomly divided into the treatment group and control group,30 cases in each group. The treatment group was treated with Qiangji Tongluo Granules,the control group was treated with compound granules(without Tripterygium Wilfordii),with a course of 3 months. The clinical efficacy was observed. The changes of related symptoms(the time of early morning stiffness,degree score of low back pain,score of total pain,swelling number of peripheral joint,overall symptom score of patients) and sign indexes(pillow-wall distance,finger-ground distance,erythrocyte sedimentation rate (ESR),C reactive protein(CRP),bath ankylosing spondylitis disease activity index(BASDAI),bath ankylosing spondylitis disease function index(BASDFI)),TCM syndrome scores were compared.  Results: ①28 cases in the treatment group and 25 cases in the control group finally completed the trials. ②The total effective rate of the treatment group and the control group were 96.43% and 64.00% respectively. There was statistically significant difference on the clinical efficacy between the two groups,and the effect of the treatment group was better than that of the control group(P<0.05). ③Comparison between the two groups after treatment,there were statistically significant differences on the time of early morning stiffness,degree score of low back pain,score of total pain,swelling number of peripheral joint,overall symptom score of patients(P<0.05),which suggested that the clinical symptoms in the treatment group were significantly relieved compared with the control group. Comparison between the two groups after treatment,there were statistically significant differences on the levels of pillow-wall distance,finger-ground distance,ESR,CRP,BASDAI and BASDFI(P<0.05),which suggested that the signs recovery in the treatment group were more significant than those in the control group. ④Comparison of the difference before and after treatment,there was statistically significant difference on the TCM syndrome scores between the two groups(P<0.05). ⑤Before and after treatment, tests for blood, urine and stool and the liver and kidney function of subjects in the two groups were normal. During the trial, no adverse reactions were found in both groups.  Conclusion: Qiangji Tongluo Granules can be used in the treatment of ankylosing spondylitis with syndrome of kidney deficiency and phlegm stasis,which significantly improve the clinical symptoms and signs of patients. Meanwhile,the effect was improved after adding Tripterygium Wilfordii to the compounds,and there was no adverse reaction in the short term.