Objective:To discuss the effects of Sijunzi Decoction on suppressing bacterial translocation and promoting bone repair in mice with bone injury. MethodsTen mice were taken as the control group from 100 healthy mice. After modeling the other 90 mice were randomly divided into the traditional Chinese medicine(TCM) group, antibiotic group and recovery group, 30 mice in each group. The antibiotic group was treated with penicillin and streptomycin by intraperitoneal injection,the TCM group was treated with Sijunzi Decoction based on the treatment for the antibiotic group, and the recovery group was treated with 0.9% normal saline by intragastric administration. 10 days after modeling, the bacterial translocation in the liver and the phagocytic function of macrophages were detected. The scar areas and bone volume fraction(BVF) of the TCM group,antibiotic group and recovery group were checked after 2 weeks, 4 weeks, 6 weeks and 8 weeks.  Results:The rate of bacterial translocation and liver living bacteria count in the TCM group were significantly lower than those in the recovery group and antibiotic group (P<0.01); the phagocytic capacity of macrophages in the TCM group was significantly higher than that in the recovery group and antibiotic group (P<0.01); the scar areas reduced most quickly in the TCM group(P<0.01); the BVF in the TCM group at different time points were all higher than that in the recovery group and antibiotic group (P<0.01).  Conclusion: Sijunzi Decoction can inhibit the bacterial translocation and improve the phagocytic function of macrophages to promote bone repair in bone damage mice.