Syndrome differentiation system of six meridians established by Treatise on Febrile Diseases pay attention to the holistic concept and systematic syndrome differentiation. Based on this system,syndrome differentiation system of classical prescription was developed and presented the connotation of accurate syndrome differentiation. Accurate syndrome differentiation,the detailed and concrete kind of systematic syndrome differentiation,emphasize the demonstration and efficacy,and realize the integration of “prescription” and “syndrome” through the prescription and drug as the main carrier,which conform to the direction of medical science development.