Objective:To observe the clinical effect of Shegan mixture in the treatment of infantile cough. Methods285 children with cough were randomly divided into the treatment group A, treatment group B and control group, 90 cases in each group. Based on conventional therapy, the treatment group A was treated with Shegan mixture, treatment group B were treated with Xuanfei Zhike mixture, while the control group was treated with oral lipid of ambrocol,additionally,with a course of 7 days. The clinical effects and the changes of TCM syndromes were observed.  Results:①15 cases were dropped totally and the expulsion rate was 5.26%(＜10%)during the experiment.Finally, 270 cases were finished, 90 cases in each group. ②The clinical total effective rate of the treatment group A, treatment group B and control group was 91.11%, 80% and 77.78%,respectively.The difference of clinical curative effect between groups was statistically significant, the effect in the treatment group A was significantly better than that in the treatment group B and control group(P<0.05).③Compared within group before and after treatment,the difference of TCM syndrome score in each group was statistically significant(P<0.05). Compared between groups after treatment,the difference of TCM syndrome score was statistically significant(P<0.05)；among,the reduction of TCM syndrome score in the treatment group A was significantly lower than that in the treatment group B and the control group(P<0.05)；there was no significant difference on the reduction of TCM syndrome score between the treatment group B and control group(P>0.05).  Conclusion:The curative effect of Shegan mixture in the treatment of infantile cough was significant,which obviously alleviated the clinical symptoms.