Objective:To investigate the repair effect of Panax notoginseng flower saponins hydrogel on skin wound. MethodsAnimal model of acute mechanical skin damage was formed by incisions of full skin in rats. Recombinant bovine basic fibroblast growth factor hydrogel (rb-bFGF) was used as a positive drug. Panax notoginseng flower saponins hydrogel(10g/L,25g/L,50g/L)was administrated by coating the wound surface,once a day and a course of 10 days. The effects of different treatments on wound healing time, wound healing rate, wound angiogenesis and wound histology were compared.  Results:Panax notoginseng flower saponins hydrogel improved wound healing rate and reduced the infection reaction of infected wound with the time and dose increasing. Pathology results showed that Panax notoginseng flower saponins hydrogel significantly promoted the absorption of wound inflammatory exudate,formation of granulation tissue and epidermal hyperplasia.  Conclusion:Panax notoginseng flower saponins hydrogel could promote the repair of skin wounds in rats.