HE Xiao-song, LIU Shi-xian, CAI Jun, et al. Protective role of “Buyang Huanwu Decoction” on the integrity of the neurovascular unit after rat brain ischemia[J]. Shanghai Journal of Traditional Chinese Medicine, 2016,50(8):78-80.
HE Xiao-song, LIU Shi-xian, CAI Jun, et al. Protective role of “Buyang Huanwu Decoction” on the integrity of the neurovascular unit after rat brain ischemia[J]. Shanghai Journal of Traditional Chinese Medicine, 2016,50(8):78-80.DOI:
Objective:To study the protective effects of “Buyang Huanwu Decoction” on the integrity of neurovascular unit after brain ischemia in rats. MethodsMCAO was established in rats and then the rats were randomized into the treatment group and control group. The treatment group was orally given “Buyang Huanwu Decoction” and the control group was orally given normal saline, with a course of seven days. The neurological score was used to test the behavioral performance, the TTC staining was used to determine the infarct area, the number of neuron and integrity of the neurovascular unit. was determined by immnuohischemstry ResultsCompared with the control group, NRSS score could reduced, the infarct area the number of neuron positive cells and the integrity of the neurovascular unit increased(P<0.05). Conclusion:“Buyang Huanwu Decoction” can promote the recovery following MCAO via improving the integrity of neuralvascular unit.