Objective:To observe the effects of Chuankezhi injection on the treatment of COPD patients in GOLD II-III stable period via different administration. Methods 90 cases of COPD patients in stable stage of grade 2-3 according to GOLD ranks were randomly divided into 3 groups, treatment group A, treatment group B and control group, 30 cases in each group . Patients in control group were treated with thiazide tiotropium powder for inhalation therapy, treatment group A was treated with Chuankezhi injection for muscle injection at gluteus maximus,and treatment group B was treated with Chuankezhi injection for acupoint injection at Zusanli. The course of treatment was 6 months. The changes of CAT score for syndrome, walking distance within 6 min(6MWD), lung function (FEV,1, FEV,1,/FVC, FEV,1,%) and TCM syndrome score were observed and compared.  Results:①Compared with the control group, the differences of CAT score and level of 6MWD in the treatment group A and B were statistical significant (P,<,0.05).Compared with the treatment group A,the CAT score in treatment group B decreased significantly and the level of 6MWD improved more obviously(P,<,0.05). ②Compared with the control group, the differences of level of FEV,1,FEV,1,/FVC,FEV,1,% in the treatment group A and B were statistical significant (P,<,0.05).Compared with the treatment group A, the level of these indicators in treatment group B increased significantly(P,<,0.05). ③Compared with the control group, the differences of TCM syndrome score in the treatment group A and B were statistical significant (P,<,0.05). Compared with the treatment group A, the TCM syndrome score in treatment group B decreased significantly(P,<,0.05).  Conclusion:Chuankezhi injection combined with thiazide tiotropium powder inhalant could be used for the treatment of COPD patients in GOLD II-III stable period,and acupoint injection showed better efficacy than intramuscular injection.