Objective:To observe the clinical efficacy of “Yangyin Huoxue Tongluo Decoction” in the treatment of chronic persistent bronchial asthma of yin-deficiency and blood-stasis. MethodsSixty subjects were randomized into treatment group(n=30) and control group(n=30); the treatment group was given “Yangyin Huoxue Tongluo Decoction” and the control group was given treated with seretide, with a course of three months. The clinical efficacy, TCM syndrome score, pulmonary function and EOS were assessed before and after treatment.  Results:①The total effective rate was 86.67% in the treatment group and 66.67% in the control group, with better efficacy in the treatment group than in the control group(P,<,0.05). ②There was a significant difference in the TCM syndrome score between the two groups after treatment(P,<,0.05). ③After treatment, the lung function(FEV,1,% and FEV,1,/FVC) was improved more significantly in the treatment group than in the treatment group(P,<,0.05). ④After treatment, the EOS count was lower in the treatment group than in the control group(P,<,0.05).  Conclusion: “Yangyin Huoxue Tongluo Decoction” acts to relieve clinical symptoms and improve lung function in the treatment of chronic persistent bronchial asthma of yin-deficiency and blood-stasis.