Objective:To observe the clinical efficacy of “Huayu Decoction” and western medicine in the treatment of myocardial injury in patients with septic shock. MethodsSixty subjects were randomized into two groups, 30 cases in each group; the control group was treated just with conventional western medicine, and the treatment group was treated with “Huayu Decoction” and conventional western medicine. After 7-day treatment, the clinical efficacy and the levels of serum myocardial injury indexes (LDH and CK - MB, cTNI) were observed.  Results:①The effective rate was 70.00% in the treatment group and 40.00% in the control group, with better efficacy in the treatment group than in the control group(P<0.05). ②Between before and 24 hours after treatment, there were no differences in the LDH and CK-MB levels in the two groups(P>0.05), but there was a difference in cTNI level in the two groups(P<0.05). Twenty-four hours after treatment, there was no statistical significance in the levels of LDH and CK - MB between the two groups(P>0.05), and significant difference in cTNI level between the two groups(P<0.05). Between before and 7 days after treatment, there were significant differences in the LDH and CK-MB levels in the treatment group(P<0.05), and there were striking differences in the LDH and cTNI levels in the control group(P<0.05). Seven days after treatment, there were statistical significances in the levels of LDH, CK-MB and cTNI between the two groups(P<0.05).  Conclusion: “Huayu Decoction” with western medicine is effective to reduce myocardial injury and improve heart function in the treatment of myocardial injury in patients with septic shock.