Objective:To observe the clinical efficacy of “Tangzu Formula” on diabetic foot ulcers. MethodsSixty cases of diabetic foot were randomly divided into treatment group(n=30) and control group(n=30). Besides the same conventional treatment, the treatment group was given oral “Tangzu Formula”, and the control group was given oral placebo granule, with a course of one month. The clinical efficacy, areas of ulcers, and WBC, Hs-CRP, D-glucan and FPG, 2hPG and HbA1C were observed.  Results:①The total effective rate was 86.67% in the treatment group and 73.33% in the control group, with better efficacy in the treatment group than in the control group(P<0.05). ②After treatment, there were significant differences in the long and short diameters between the two groups(P<0.05). ③After treatment, there was statistical significance in 2hPG, WBC, Hs-CRP and D-glucan between the two groups(P<0.05), with lower levels in treatment group than in the control group(P<0.05).  Conclusion: “Tangzu Formula” with western medicine is effective in treating diabetic foot ulcers by inhibiting inflammatory reaction and promoting ulcer healing.