Objective:To observe the clinical efficacy and safety of “Yiqi Jiedu Quyu Decoction” and thalidomide in the treatment of Behcet’s disease. MethodsForty cases of Behcet’s disease of qi-deficiency and blood-toxin were randomized into two groups:control group in which 20 cases were treated with thalidomide at the dose of 50mg/d, and treatment group in which 20 cases were treated with “Yiqi Jiedu Quyu Decoction” and thalidomide, with a course of three months. The clinical efficacy, attack frequency of oral ulcers, remission period and oral ulcers, ESR, C-reactive protein and side effects were observed.  Results:The total effective rate in the treatment group(95.00%) was higher than that in the control group(85.00%), with a significant difference between them(P<0.05). After treatment, the the oral ulcers, ESR and C-reactive protein were improved in both groups(P<0.05), with longer remission period and lower ESR in the treatment group than in the control group(P<0.05); the incidence of side effect in the treatment group(5%) was lower than that in the control group(25%)(P<0.05).  Conclusion:“Yiqi Jiedu Quyu Decoction”with thalidomide is quite effective and safe for Behcet’s disease in lowering ESR and prolonging remission period of oral ulcers.