Objective:To evaluate the clinical effects of “Jiawei Zuogui Pill” in the treatment of postmenopausal osteoporosis of kidney-yin deficiency. MethodsEighty subjects were randomly divided into two groups. The treatment group(40 cases) was treated with “Jiawei Zuogui Pill” and calcium carbonate D,3, while the control group (40 case) was treated with calcium carbonate D,3, only . Both groups were treated for one year. The changes of bone mineral density(BMD) (L,2,-L,4, and hip femoral neck and Ward’s triangle), the score of traditional Chinese Medcine(TCM) syndrome, estradiol (E,2,), 25 hydroxy vitamin D,3, [25 (OH)VitD,3,], antitartaric acid phosphatase (TRACP), bone alkaline phosphatase (BALP) and other biochemical indexes were compared.  Results:①The level of BMD(L,2,-L,4, neck of femur and Ward’s region) increased significantly in treatment group compared with control group after treatment(P,<,0.05). ② Compared before and after treatment within groups, the score of TCM syndrome in each group decreased significantly(P,<,0.05). Compared with the control group, the reduction of the score in treatment group was more remarkable(P,<,0.05).③Compared before and after treatment, the level of 25(OH)D,3, increased significantly(P,<,0.05), while TPACP and BALP decreased significantly(P,<,0.05) in treatment group. There was no significant change in control group.  Conclusion:“Jiawei Zuogui Pill” can increase BMD and relieve the symptoms of kidney-yin deficiency in the treatment of postmenopausal osteoporosis.