This paper explores the therapy and syndromes of numbness due to depression syndrome. It indicates that apart from disharmony between ying and wei,and qi and blood,phlegm-stasis obstruction,and wind-dampness obstruction,the pathogenesis of numbness can also be connected to anxiety,terror,depression,irascibility,heart vacuity and discomposure and so on,which can all lead to numbness,so we should treat numbness from the aspect of depression syndrome. The location,sensation,degree,beginning and ending time,attack,and associated symptoms of numbness due to depression syndrome all have similar characteristics as depression syndrome in different degree. Numbness due to depression syndrome can be found in many mental disorders,such as melancholia,panic disorder of anxiety neurosis,somatoform disorders,and limb perceive abnormality in modern medicine.