Objective:To investigate effects of Electroacupuncture(EA)combined with general anesthesia(GA)strategy on oxygenation and pulmonary shunt during one-lung ventilation in patients with thoracic surgery. MethodsSixty patients with thoracic surgery were randomly divided into EA group and GA group,with 30 cases in each group.Patients of the GA group received simple general anesthesia.EA(2/100 Hz)was applied to bilateral Houxi(SI03),Zhigou(SJ6),Neiguan(PC6),and Hegu(LI4)beginning about 30 min before the surgery in the EA group.Blood samples were obtained at four time points:two lung ventilation 0 min(T,0,),one-lung ventilation 15 min(T,1,),one-lung ventilation 30 min(T,2,),one-lung ventilation 60 min(T,3,)via internal jugular vein and radial artery to perform blood gas analysis.Intrapulmonary shunt(Q,s,/Q,t,)was calculated and detected.  Results:①Compared to the two lung ventilation(T,0,), there was no significant difference in the MAP, HR, CVP, Paw, pH, PaCO,2, PvO,2, SvO,2, and Hb in both group during the one-lung ventilation(T,1,-T,3,)(P,>,0.05); There was also no significant difference between the two groups at the same time points(P,>,0.05). ②Compared to the T,0, the partial pressure of oxygen(PaO,2,)was significantly reduced at T,1, T,2, and T,3, in each group(P,<,0.05); In GA group, the PaO,2, was reached the lowest value at T,2, and then began to increase; However, in EA group, the PaO,2, was reached the lowest value at T,3,; Meanwhile, compared to the GA group,the PaO,2, was significantly higher at the time points T,1,T,2,and T,3, in EA group(P,<,0.05); During the one-lung ventilation, there was no significant difference in SaO,2, between the two groups at T,1, T,2, and T,3,(P,>,0.05). ③There was no significant difference in Q,s,/Q,t, between the two groups before surgery(P,>,0.05), and both were in the normal range. After one lung ventilation, Q,s,/Q,t, value increased significantly(P,<,0.05). The peak value of Q,s,/Q,t, in EA group was at 15 min(T,1,)after one lung ventilation, while the peak of pulmonary shunt occurred at 30 min(T,2,)in GA group. The Q,s,/Q,t, value in EA group was significantly lower than that in GA group at T,1, T,2, T,3, with a significant difference between two groups(P,<,0.05).  Conclusion:EA combined with general anesthesia can increase the PaO,2, and reduce intrapulmonary shunt during one-lung ventilation in patients undergoing thoracic surgery.It has positive effects on lung protection in clinical practice.