Objective:To observe the clinical curative effect of the treatment in nonalcoholic fatty liver disease treated with “Jianpi Moji Decoction” combined with western medicine. Methods 60 NAFLD cases were randomly divided into control group and treatment group, 30 cases were in each group. Each case was given Essentiale, meanwhile the treatment group was given “Jianpi Moji Decoction” on the basis treatment, and both treated for 3 months. The changes of liver function, lipids profile, endotoxin and TNF-α, IL-6, IL-8 levels and TCM syndrome integral of two groups before and after treatment were observed.  Results: ① Compared before and after treatment in each group, there was significant difference in levels of ALT, GGT and TG in treatment group (P<0.05) and ALT and TG level in the control group (P<0.05). Compared between two groups after treatment, there was significant difference in levels of ALT and TG (P<0.05). ②Compared beteeen the two groups before and after treatment, the endotoxin and TNF alpha, IL-6 and IL 8 level was significantly different in treatment group (P<0.05), and endotoxin was significantly different in the control group (P<0.05); Compared between two groups after treatment, endotoxin and TNF alpha, IL-6 and IL-8 level was significantly different and the treatment group was improved more significant than control group (P<0.05). ③Compared before and after treatment in each group, the score of bilges full, side rib pain, stay, eat less, languid was significantly different in the treatment group (P<0.05). Compare with two groups, and the syndrome was significantly improved in treatment group than that of control group (P<0.05).  Conclusion: “Jianpi Moji Decoction” combined with western medicine can significantly relieve the clinical symptoms, improve liver function, reduce the lipid profile level in treating nonalcoholic fatty liver disease, and the mechanism of ‘JianPiMoJi’ “Jianpi Moji Decoction” may be related to reduce the leakage of endotoxin about the bowel “second hit”.