Objective:To observe the effects of “Buxue Huoxue Decoction” on liver function and hepatic fibrosis in patients with chronic hepatitis B. Methods A total of 186 patients with chronic hepatitis B were randomized into observation group (86 cases) and control group (80 cases). The control group was given diammonium glycyrrhizinate, and the observation group was given “Buxue Huoxue Decotion” based on the control group. After 3-month treatments, the clinical efficacy and the indexes of liver function and hepatic fibrosis were observed before and after treatment.  Results: ①The total effective rate was 93.02% in the observation group and 81.25% in the control group, with better efficacy in the observation group than in the control group(P<0.05); ②After treatment, the indexes of liver function were decreased in both groups(P<0.05), with more significant decrease in the observation group than in the control group(P<0.05); ③After treatment, the indexes of hepatic fibrosis were decreased in both groups(P<0.05), with more significant decrease in the observation group than in the control group(P<0.05).  Conclusion: “Buxue Huoxue Decoction” is quite effective for chronic hepatitis, and acts to protect liver function and suppress hepatic fibrosis.